American Board of Psychiatry and Neurology (ABPN) Practice Exam

Gabapentin is recommended as a preferred pharmacologic treatment for postherpetic neuralgia due to its mechanism of action and efficacy in managing neuropathic pain. Gabapentin works by inhibiting certain calcium channels in the central nervous system, which helps to reduce the release of excitatory neurotransmitters. This action can lead to decreased pain signaling and ultimately provides relief to patients suffering from postherpetic neuralgia, a complication that arises following an outbreak of shingles (herpes zoster). The effectiveness of gabapentin in this context is well-supported by clinical studies, which have shown improved pain scores and enhanced quality of life for patients experiencing this condition. Given that postherpetic neuralgia can be quite debilitating, the use of gabapentin can help to alleviate symptoms, making it a preferred option. Other agents may also be utilized for treatment, but their efficacy and the specific nature of their action may not align as closely with the needs of patients suffering from postherpetic neuralgia. For instance, while duloxetine is an effective treatment for various neuropathic pain syndromes and fibromyalgia, it is commonly used for conditions involving mood disorders and generalized anxiety rather than specific neuropathic pains related to postherpetic neural